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Von Reyn Criteria: Sensitivity and Specificity

Introduction: None written. Excerpt from the entry in Infective Endocarditis:
Definite, Probable, or Possible (less sens, more spec if disregard 'possible')
  • Definite: direct evidence of infective endocarditis based on histology from surgery or autopsy or on bacteriology (Gram's stain or culture) of valvular vegetation or peripheral embolus
  • Probable: (a) persistently positive blood culture, plus one of: new regurgitant murmur; predisposing heart disease and vascular phenomena (petechiae, splinter haemorrhages, conjunctival haemorrhages, Roth spots, Osler's nodes, Janeway lesions, aseptic meningitis, glomerulonephritis and pulmonary, CNS, coronary or peripheral emboli) . (b) negative or intermittently positive blood cultures plus three of the following: fever; new regurgitant murmur; vascular phenomena
  • Possible: (a) persistently positive blood cultures plus one of the following: predisposing heart disease; vascular phenomena. (b) negative or intermittently positive blood cultures with all three of the following: fever; predisposing heart disease; valvular phenomena, (c) for viridans streptococcal cases only- at least two positive blood cultures without an extra-cardiac source and fever
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    Associated Diagnoses:

    Infective Endocarditis

    69% sensitive, 92% specific