Infective Endocarditis: Sensitivity and Specificity
Introduction: Endocarditis refers to bacterial infection of the heart valves, manifested by vegetations of bacteria growing on the valves. Endocarditis will cause bacteremia and septic emboli; it may also destroy the valve involved.
Nowadays, the Duke Criteria are the clinical 'gold standard' diagnostic test (though obviously, pathology is the true gold standard) - but note that the Duke criteria are certainly not completely sensitive and may be nonspecific, depending on the case series (see below). The two papers cited below disagree about whether 'possible' endocarditis by Duke criteria should be considered as truly positive or not.
|Population / Calculator||Prevalence||Comments / Study / Link|
|Patients given TTE with suspicion of endocarditis||4%||Q J Med 2006; 99:23–31. PMID 16330508|