Elevated Serum Methylmalonic Acid or Homocysteine: Sensitivity and Specificity
Introduction:
None written. Excerpt from the entry in Megaloblastic Macrocytic Anemia:
either elevated: MMA > 376 nM, HCys > 21.3 uM. In patients with MCV > 100.
either elevated: MMA > 376 nM, HCys > 21.3 uM. In patients with MCV > 100.
Extreme elevations found solely in B12 deficiency. False positives occur often from renal failure or hypovolemia.
Associated Diagnoses:
Megaloblastic Macrocytic Anemia
89% sensitive, 73% specific