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Elevated Serum Methylmalonic Acid or Homocysteine: Sensitivity and Specificity

Introduction: None written. Excerpt from the entry in Megaloblastic Macrocytic Anemia:
either elevated: MMA > 376 nM, HCys > 21.3 uM. In patients with MCV > 100.

Extreme elevations found solely in B12 deficiency. False positives occur often from renal failure or hypovolemia.

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Associated Diagnoses:

Megaloblastic Macrocytic Anemia

89% sensitive, 73% specific