Megaloblastic Macrocytic Anemia: Sensitivity and Specificity
Introduction: This is one of the principal mainfestations of Vitamin B12 (cobalamin) deficiency. It is the sole manifestation of Folate Deficiency in the adult. The other major manifestation of B12 deficiency is neurological: subacute combined degeneration of the spinal column and/or dementia. One common cause of B12 deficiency is Pernicious Anemia.
Other causes of macrocytic anemia include Alcoholism, reticulocytosis, and MDS.