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Specific Findings

Neuromyelitis Optica: Sensitivity and Specificity

Introduction: also known as Devic Disease. It is usually viewed as a subtype of multiple sclerosis only involving the optic nerve and cervical spinal cord. Most cases are relapsing, and the initial presentation may involve only one component of the syndrome.

Revised diagnostic criteria for NMO published in 2006 require optic neuritis, myelitis, and at least two of three supportive criteria:

* A contiguous spinal cord lesion on MRI extending three or more segments

* Initial brain MRI not meeting usual diagnostic criteria for MS

* Seropositivity for NMO-IgG

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The sensitivity and specificity of findings for Neuromyelitis Optica are listed below. See the left navigation bar to change the display.

Specific Findings

Finding SensitivitySpecificity Comments, Study
NMO-IgG Edit 73%91%

this is an antibody directed against Aquaporin 4 (present in astrocytes at the BBB).

Study: Lancet 2004 Dec 11;364(9451):2106-12. PMID 15589308