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Neonatal Sepsis: Sensitivity and Specificity

Introduction: 90% of neonatal sepsis occurs within 24 hours of delivery. Mostly from group B Streptococcus. If there is suspicion of neonatal sepsis, infants should get blood cx, LP, and CBC, CRP, etc.

If mom has risk factors, then mom should be given ampicillin 1g at least 4 hours prior to delivery. Infants at risk should be monitored for at least 48 hours.

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Tags: Infection Pediatrics Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Live Births 0.08% Adv Neonatal Care. 2003 Feb;3(1):3-13. PMID: 12882177
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The sensitivity and specificity of findings for Neonatal Sepsis are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
Serial CRP
Duplicate Edit
89%98%

8 hours apart. For early-onset sepsis

Study: Adv Neonatal Care. 2003 Feb;3(1):3-13. PMID: 12882177

Specific Findings

Finding SensitivitySpecificity Comments, Study
Elevated CRP
Duplicate Edit
62%92%

inital CRP, for late-onset sepsis

Study: Adv Neonatal Care. 2003 Feb;3(1):3-13. PMID: 12882177

Elevated CRP
Duplicate Edit
35%90%

initial, for early-onset sepsis

Study: Adv Neonatal Care. 2003 Feb;3(1):3-13. PMID: 12882177

Sensitive Findings

Finding SensitivitySpecificity Comments, Study
Serial CRP
Duplicate Edit
96%72%

8 hours apart. For late-onset sepsis.

Study: Adv Neonatal Care. 2003 Feb;3(1):3-13. PMID: 12882177

Serial CRP and IL-8 Edit 93%80%

both elevated

Study: Adv Neonatal Care. 2003 Feb;3(1):3-13. PMID: 12882177

Poorly Diagnostic Findings

Finding SensitivitySpecificity Comments, Study
Elevated ESR Edit 63%60%

"micro-ESR"

Study: Mymensingh Med J. 2009 Jan;18(1):56-61. PMID: 19182751

Elevated I/T Ratio Edit 70%56%

immature / total polys

Study: Mymensingh Med J. 2009 Jan;18(1):56-61. PMID: 19182751