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Neonatal Sepsis: Sensitivity and Specificity

Introduction: 90% of neonatal sepsis occurs within 24 hours of delivery. Mostly from group B Streptococcus. If there is suspicion of neonatal sepsis, infants should get blood cx, LP, and CBC, CRP, etc.

If mom has risk factors, then mom should be given ampicillin 1g at least 4 hours prior to delivery. Infants at risk should be monitored for at least 48 hours.

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Tags: Infection Pediatrics Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Live Births 0.08% Adv Neonatal Care. 2003 Feb;3(1):3-13. PMID: 12882177
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The sensitivity and specificity of findings for Neonatal Sepsis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Serial CRP + 0 - 89%98%
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Elevated CRP + 0 - 62%92%
[ + ] Elevated CRP + 0 - 35%90%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Serial CRP + 0 - 96%72%
[ + ] Serial CRP and IL-8 + 0 - 93%80%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Elevated ESR + 0 - 63%60%
[ + ] Elevated I/T Ratio + 0 - 70%56%