GetTheDiagnosis.org

Welcome, guest.
Login or Sign up to edit.

Add an entry

Search:
 

Tools

Add a finding for this diagnosis

Add prevalence for this diagnosis

Switch to calculator mode to see positive predictive value

Switch to likelihood ratios

Sort findings by Tag

Sort findings by Differential Diagnosis

Jump To

Sensitive and Specific Findings

Findings With Unspecified Accuracy

Human Immunodeficiency Virus: Sensitivity and Specificity

Introduction: None written.

[Edit Diagnosis] [Merge dx] [Add prevalence]

Tags: Infection Tag this Diagnosis.

The sensitivity and specificity of findings for Human Immunodeficiency Virus are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
p24 Antigen Edit 89%100%

Study: Ann Intern Med 2001 Jan 2;134(1):25-9. PMID 11187417

Blood Rapid Antibody Test Edit 99.7%99.9%

from whole blood

Study: AIDS. 2006 Aug 1;20(12):1655-1660. PMID 16868447

Western Blot Edit 99.3%99.7%

'window period' of seronegativity is approximately 3-6 weeks in newest-generation assays. p24 antigen should be sensitive in this timeframe.

Study: CDC Survey, cited in UpToDate

http://www.utdol.com/online/content/topic.do?topicKey=hiv_infe/5102

HIV RNA PCR Edit 100%97%

All false positives had levels < 2000 copies/ml.

Study: Ann Intern Med 2001 Jan 2;134(1):25-9. PMID 11187417

Oral Rapid Antibody Test Edit 99.9%96.9%

aka "OraSure" or "OraQuick" . Another study found sens = 99.1% and spec = 99.6%.

Study: sens: JAMA 1997 Jan 15;277(3):254-8. PMID 9005276

spec: Ann Intern Med. 2008 Aug 5;149(3):153-60. PMID 18678842

alternative: AIDS. 2006 Aug 1;20(12):1655-1660. PMID 16868447

Findings With Unspecified Accuracy

Finding SensitivitySpecificity Comments, Study
Thrush Edit No accuracy specified.

Study: no study specified.

Salivary gland enlargement, bilateral Edit No accuracy specified.

Study: no study specified.