Hepatocellular Carcinoma: Likelihood Ratios

Introduction: Hepatocellular carcinoma often occurs in cirrhotics, though patients with Hepatitis C may develop HCC without Cirrhosis.

Prevalence

The likelihood ratios of findings for Hepatocellular Carcinoma are listed below. See the left navigation bar to change the display.

Good Positive and Negative Likelihood Ratios

Finding	+LR	-LR	Comments, Study
Abdominal MRI	inf	0	Recent performance at one institution. Sensitivity for lesions <2 cm was 82.6% Older literature has sensitivity = 81%, specificity = 85% Study: Radiology. 2011 Dec;261(3):824-33. Epub 2011 Oct 3. PMID 21969663 Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288
Abdominal US	12.7	0.2	hepatitis B Study: Hepatology 1995 Aug;22(2):432-8. PMID 7543434
Abdominal CT	9.7	0.3	Study: Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288
AFP Duplicate	6.7	0.4	AFP > 20 in patients with chronic liver disease Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657
AFP Duplicate	5.6	0.4	AFP > 16 mcg/L, in pts with chronic liver disease Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

Good Positive Likelihood Ratio

0.7

AFP > 100 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

0.8

AFP > 200 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657