Hepatocellular Carcinoma: Likelihood Ratios

Introduction: Hepatocellular carcinoma often occurs in cirrhotics, though patients with Hepatitis C may develop HCC without Cirrhosis.

Prevalence

The likelihood ratios of findings for Hepatocellular Carcinoma are listed below. See the left navigation bar to change the display.

Imaging

Finding	+LR	-LR	Comments, Study
Abdominal CT	9.7	0.3	Study: Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288
Abdominal MRI	inf	0	Recent performance at one institution. Sensitivity for lesions <2 cm was 82.6% Older literature has sensitivity = 81%, specificity = 85% Study: Radiology. 2011 Dec;261(3):824-33. Epub 2011 Oct 3. PMID 21969663 Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288
Abdominal US	12.7	0.2	hepatitis B Study: Hepatology 1995 Aug;22(2):432-8. PMID 7543434

Tumor Marker

Finding	+LR	-LR	Comments, Study
AFP Duplicate	5.6	0.4	AFP > 16 mcg/L, in pts with chronic liver disease Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657
AFP Duplicate	6.7	0.4	AFP > 20 in patients with chronic liver disease Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657
AFP Duplicate	31	0.7	AFP > 100 in patients with chronic liver disease Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657
AFP Duplicate	22	0.8	AFP > 200 in patients with chronic liver disease Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657