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Sensitive and Specific Findings

Specific Findings

Findings With Unspecified Accuracy

Hepatocellular Carcinoma: Sensitivity and Specificity

Introduction: Hepatocellular carcinoma often occurs in cirrhotics, though patients with Hepatitis C may develop HCC without Cirrhosis.

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Tags: Hepatic Neoplasm Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Cirrhosis 3% per year

N Engl J Med 1991 Sep 5;325(10):675-80. PMID 1651452

Chronic Hepatitis 1.3% per year

N Engl J Med 1993 Jun 24;328(25):1797-801. PMID 7684822

More, Edit...

The sensitivity and specificity of findings for Hepatocellular Carcinoma are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
Abdominal MRI Edit 97.1%100%

Recent performance at one institution. Sensitivity for lesions <2 cm was 82.6%

Older literature has sensitivity = 81%, specificity = 85%

Study: Radiology. 2011 Dec;261(3):824-33. Epub 2011 Oct 3. PMID 21969663

Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288

Specific Findings

Finding SensitivitySpecificity Comments, Study
AFP
Duplicate Edit
31%99%

AFP > 100 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

AFP
Duplicate Edit
22%99%

AFP > 200 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

Abdominal US Edit 78.8%93.8%

hepatitis B

Study: Hepatology 1995 Aug;22(2):432-8. PMID 7543434

Abdominal CT Edit 68%93%

Study: Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288

AFP
Duplicate Edit
60%91%

AFP > 20 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

AFP
Duplicate Edit
62%89%

AFP > 16 mcg/L, in pts with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

Findings With Unspecified Accuracy

Finding SensitivitySpecificity Comments, Study
Ferritin, high Edit No accuracy specified.

Study: no study specified.