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Good Positive and Negative Likelihood Ratios

Good Positive Likelihood Ratio

Findings With Unspecified Accuracy

Hepatocellular Carcinoma: Likelihood Ratios

Introduction: Hepatocellular carcinoma often occurs in cirrhotics, though patients with Hepatitis C may develop HCC without Cirrhosis.

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Tags: Hepatic Neoplasm Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Cirrhosis 3% per year

N Engl J Med 1991 Sep 5;325(10):675-80. PMID 1651452

Chronic Hepatitis 1.3% per year

N Engl J Med 1993 Jun 24;328(25):1797-801. PMID 7684822

More, Edit...

The likelihood ratios of findings for Hepatocellular Carcinoma are listed below. See the left navigation bar to change the display.

Good Positive and Negative Likelihood Ratios

Finding +LR-LR Comments, Study
Abdominal MRI Edit inf0

Recent performance at one institution. Sensitivity for lesions <2 cm was 82.6%

Older literature has sensitivity = 81%, specificity = 85%

Study: Radiology. 2011 Dec;261(3):824-33. Epub 2011 Oct 3. PMID 21969663

Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288

Abdominal US Edit 12.70.2

hepatitis B

Study: Hepatology 1995 Aug;22(2):432-8. PMID 7543434

Abdominal CT Edit 9.70.3

Study: Am J Gastroenterol. 2006 Mar;101(3):513-23. PMID: 16542288

AFP
Duplicate Edit
6.70.4

AFP > 20 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

AFP
Duplicate Edit
5.60.4

AFP > 16 mcg/L, in pts with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

Good Positive Likelihood Ratio

Finding +LR-LR Comments, Study
AFP
Duplicate Edit
310.7

AFP > 100 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657

AFP
Duplicate Edit
220.8

AFP > 200 in patients with chronic liver disease

Study: J Hepatol 2001 Apr;34(4):570-5. PMID 11394657