Welcome, guest.
Login or Sign up to edit.

Add an entry



Add a finding for this diagnosis

Add prevalence for this diagnosis

Switch to calculator mode to see positive predictive value

Switch to likelihood ratios

Sort findings by Accuracy

Sort findings by Tag

Jump To


Hepatitis C: Sensitivity and Specificity

Introduction: None written.

[Edit Diagnosis] [Merge dx] [Add prevalence]

Tags: Hepatic Infection Tag this Diagnosis.

The sensitivity and specificity of findings for Hepatitis C are listed below. See the left navigation bar to change the display.


Finding SensitivitySpecificity Comments, Study
Anti-HCV Ab Edit 92%93%

first-generation enzyme immunoassay, vs HCV PCR

Second generation tests are more sensitive (~95%) and reportedly more specific - PPV in high risk pool ~88% or 50% in lower risk pool.

The mean time to seroconversion improves with the generation (16 wk with 1st gen, 10wk with 2nd gen, and 8wk in 3rd gen) per UpToDate (

Study: J Clin Microbiol 1992 Aug;30(8):2145-9. PMID 1323578

Hepatology 1997 Sep;26(3 Suppl 1):43S-47S. PMID 9305663

Elevated Serum Transaminases Edit 80%32%

vs RIBA gold standard

Study: J Clin Microbiol 1992 Aug;30(8):2145-9. PMID 1323578

HCV Ab RIBA Edit 94%94%

RIBA (recombinant immunoblot assay), vs HCV PCR

RIBA is not intended to be used as a screening test but rather as a confirmatory test. In addition, note that there are 3 outcomes of RIBA: positive (>= 2 antigens reactivity), intermediate (1 antigen reactive), or negative. Intermediate RIBA does carry a higher PPV than negative but lower than a positive test.

Study: J Clin Microbiol 1992 Aug;30(8):2145-9. PMID 1323578

HCV RNA Edit No accuracy specified.

now considered the "gold standard" - though note that some patients can have +ELISA and negative RNA PCR. In these patients, RIBA should be done to confirm past/current infection.

Study: UpToDate