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Anti-HCV Ab: Sensitivity and Specificity

Introduction: None written. Excerpt from the entry in Hepatitis C:
first-generation enzyme immunoassay, vs HCV PCR

Second generation tests are more sensitive (~95%) and reportedly more specific - PPV in high risk pool ~88% or 50% in lower risk pool.

The mean time to seroconversion improves with the generation (16 wk with 1st gen, 10wk with 2nd gen, and 8wk in 3rd gen) per UpToDate (

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Associated Diagnoses:

Hepatitis C

92% sensitive, 93% specific