Anti-HCV Ab: Sensitivity and Specificity
first-generation enzyme immunoassay, vs HCV PCR
Second generation tests are more sensitive (~95%) and reportedly more specific - PPV in high risk pool ~88% or 50% in lower risk pool.
The mean time to seroconversion improves with the generation (16 wk with 1st gen, 10wk with 2nd gen, and 8wk in 3rd gen) per UpToDate (http://www.uptodate.com/online/content/topic.do?topicKey=heptitis/8251).
92% sensitive, 93% specific