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Gout: Sensitivity and Specificity

Introduction: None written.

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Tags: Inflammatory Musculoskeletal Tag this Diagnosis.

The sensitivity and specificity of findings for Gout are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Sensitive and Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Podagra	+ 0 -	96%	97%
i.e. clinical acute involvement of the great toe Study: Ann Rheum Dis. 2006 Oct;65(10):1301-11. PMID: 16707533

Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Monosodium Urate Crystals	+ 0 -	84%	100%
in synovial fluid during an acute attack Study: Ann Rheum Dis. 2006 Oct;65(10):1301-11. PMID: 16707533
[ + ] Monosodium Urate Crystals	+ 0 -	70%	95%
from synovial fluid in asymptomatic patients, i.e. in between attacks Study: Ann Rheum Dis. 2006 Oct;65(10):1301-11. PMID: 16707533

Poorly Diagnostic Findings
Finding	Result	Sensitivity	Specificity
[ + ] Uric Acid	+ 0 -	67%	78%
uric acid > 6 mg/dl in aymptomatic patients. Measuring levels in acute attacks is not recommended, as they can be normal. Note that cutoffs depend on gender and age. Study: Ann Rheum Dis. 2006 Oct;65(10):1301-11. PMID: 16707533

Findings With Unspecified Accuracy
Finding	Result	Sensitivity	Specificity
[ + ] Tophus on pinna		No accuracy specified.
Tophus may exude a chalky white substance if squeezed Study: no study specified.