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Ethylene Glycol Poisoning: Sensitivity and Specificity

Introduction: None written.

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Tags: Metabolic Toxic Tag this Diagnosis.

The sensitivity and specificity of findings for Ethylene Glycol Poisoning are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Sensitive Findings
Finding	Result	Sensitivity	Specificity
[ + ] Elevated Osmolal Gap	+ 0 -	85%	50%
Using equation: Osmc = 2Na(mEq/L) + BUN(mmol/L) + glucose(mmol/L) + 1.25ethanol(mmol/L) OR (in US units) - Osmc (mOsm/kg) = 2(Na+) + [BUN/2.8] + [glucose/18] + 1.25[ethanol (mg/dL)/4.6] Normal is <= 10 mOsm/kg. This is for identifying patients requiring an antidote for overdose. Study:* BMC Emerg Med. 2008 Apr 28;8:5. PMID: 18442409

Poorly Diagnostic Findings
Finding	Result	Sensitivity	Specificity
[ + ] Urine Fluorescence	+ 0 -	38%	70%
under UV light (Wood's lamp) - only applicable if ingestion was antifreeze, which has Na Fluorescein added! This study was simulated, not actual poisoning patients. Study: Ann Emerg Med. 2001 Jul;38(1):49-54. PMID: 11423812
[ + ] Calcium Oxalate Crystals		Sensitivity = 50%
envelope shaped. Could not read abstract/text, but citation in Rosen's Emergency Med says <50% sensitivity. No specificity. Study: Scand J Clin Lab Invest. 1982 May;42(3):231-4. PMID: 7134806