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Choledocholithiasis: Sensitivity and Specificity

Introduction: Stones in the common bile duct, causing obstruction of bile flow out of the liver. Consequences of this include - besides simply Extrahepatic Biliary Obstruction - Acute Pancreatitis and acute cholangitis.

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Tags: Hepatic Tag this Diagnosis.

Differential Diagnoses include: Extrahepatic Biliary Obstruction

The sensitivity and specificity of findings for Choledocholithiasis are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
Endoscopic Ultrasound Edit 96%95%

Differential Diagnosis: Extrahepatic Biliary Obstruction

Study: Abdom Imaging. 2008 Jan-Feb;33(1):6-9. PMID: 17874159

MRCP
Duplicate Edit
87%95%

MRCP done with slices <= 3 mm or 3D MRCP

Differential Diagnosis: Extrahepatic Biliary Obstruction

Study: Abdom Imaging. 2008 Jan-Feb;33(1):6-9. PMID: 17874159

Bile Duct Dilatation Edit 89%89%

internal bile duct diameter on ultrasonography of less than or equal to 5 mm up to age 50 years, increasing by 1 mm per decade, was considered normal

Study: Br J Surg. 1995 Oct;82(10):1371-3 PMID: 7489169

Specific Findings

Finding SensitivitySpecificity Comments, Study
Elevated LFTs Edit 46%98%

at least 2 of: bilirubin, AP, ALT

Study: Br J Surg. 1995 Oct;82(10):1371-3 PMID: 7489169

Sensitive Findings

Finding SensitivitySpecificity Comments, Study
Bile Duct Dilatation or Any Elevated LFT Edit 96%78%

bile duct >5mm (+1 / decade over 50); LFTs: bilirubin, ALT, or AP

Study: Br J Surg. 1995 Oct;82(10):1371-3 PMID: 7489169

Poorly Diagnostic Findings

Finding SensitivitySpecificity Comments, Study
MRCP
Duplicate Edit
40%80%

MRCP with >= 5mm slices

Differential Diagnosis: Extrahepatic Biliary Obstruction

Study: Abdom Imaging. 2008 Jan-Feb;33(1):6-9. PMID: 17874159