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Sensitive and Specific Findings

Specific Findings

Cervical Cancer: Sensitivity and Specificity

Introduction: Screening tests center on finding atypical cells or cervical intraepithelial neoplasia (up to squamous carcinoma in situ). The tests listed here are generally for finding atypia and/or CIN. The pathogenesis of cervical cancer is always or almost always from HPV infection.

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Tags: Gynecologic Neoplasm Tag this Diagnosis.

The sensitivity and specificity of findings for Cervical Cancer are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
HPV DNA PCR Edit 94.6%94.1%

Study: N Engl J Med. 2007 Oct 18;357(16):1579-88. PMID: 17942871

Pap Smear Plus HPV PCR Edit 100%92.5%

Study: N Engl J Med. 2007 Oct 18;357(16):1579-88. PMID: 17942871

Specific Findings

Finding SensitivitySpecificity Comments, Study
ThinPrep Pap Smear Edit 76%86%

Note that different studies disagree on whether ThinPrep is truly better than conventional Pap smears.

Study: Gynecol Oncol. 2003 Jul;90(1):137-44. PMID 12821354

Traditional Pap Smear Edit 30%86%

Sensitivity 30-87%, spec 86-100% depending on study.

In (N Engl J Med. 2007 Oct 18;357(16):1579-88. PMID: 17942871) the sensitivity was 55.4% with specificity of 92.5%.

Study: Ann Intern Med 2000 May 16;132(10):810-9. PMID 10819705