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Sensitive and Specific Findings

CNS Toxoplasmosis: Sensitivity and Specificity

Introduction: Infection of the brain parenchyma by Toxoplasma, almost exclusively seen in HIV/AIDS patients. Often presents as a ring-enhancing lesion.

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Tags: Infection Neurologic Tag this Diagnosis.

Differential Diagnoses include: Lymphoma, CNS

The sensitivity and specificity of findings for CNS Toxoplasmosis are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
PET/CT scan Edit 90.9%100%

in patients with HIV, versus CNS lymphoma

Differential Diagnosis: Lymphoma, CNS

Study: Eur J Nucl Med Mol Imaging. 2013 Sep;40(9):1420-7. PMID: 23685752

Thallium-201 SPECT Edit 100%90%

However, an abstract found that thallium overdiagnoses lymphoma (5/8 patients thought to have toxoplasmosis by Thallium were found to have lymphoma by PET/CT).

Differential Diagnosis: Lymphoma, CNS

Study: J Nucl Med. 1996 Jul;37(7):1150-4. PMID: 8965186

J Nucl Med. 2006; 47 (Supplement 1):303P