Anaphylaxis: Sensitivity and Specificity

Introduction: None written.

The sensitivity and specificity of findings for Anaphylaxis are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

94.1%

92.3%

tryptase > 8.23 ng/ml (cutoff of 13 ng/ml decreased sensitivity to 35% without increasing specificity)

patients with a clinical allergic rxn < 6 hr in duration - anaphylaxis versus angioedema or urticaria

Study: Allergy. 1999 Jun;54(6):602-6. PMID: 10435474

Specific Findings

Finding	Sensitivity	Specificity	Comments, Study
Serial Serum Tryptase	73%	98%	increase > 2 mcg/l from 15 min to 60 min post exposure Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726
Serum Tryptase Duplicate	55%	93%	peak tryptase > 9 mcg/l (15 min and 60 min timepoints) Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726
Serum Tryptase Duplicate	36%	93%	peak tryptase > 12 mcg/l (15 and 60 min timepoints) Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726