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Sensitive and Specific Findings

Specific Findings

Anaphylaxis: Sensitivity and Specificity

Introduction: None written.

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Tags: Autoimmune Tag this Diagnosis.

The sensitivity and specificity of findings for Anaphylaxis are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
Serum Tryptase
Duplicate Edit
94.1%92.3%

tryptase > 8.23 ng/ml (cutoff of 13 ng/ml decreased sensitivity to 35% without increasing specificity)

patients with a clinical allergic rxn < 6 hr in duration - anaphylaxis versus angioedema or urticaria

Study: Allergy. 1999 Jun;54(6):602-6. PMID: 10435474

Specific Findings

Finding SensitivitySpecificity Comments, Study
Serial Serum Tryptase Edit 73%98%

increase > 2 mcg/l from 15 min to 60 min post exposure

Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726

Serum Tryptase
Duplicate Edit
55%93%

peak tryptase > 9 mcg/l (15 min and 60 min timepoints)

Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726

Serum Tryptase
Duplicate Edit
36%93%

peak tryptase > 12 mcg/l (15 and 60 min timepoints)

Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726