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Repetitive Nerve Stimulation: Sensitivity and Specificity

Introduction: None written. Excerpt from the entry in Myasthenia Gravis:
For generalized myasthenia, sensitivity ranges 53-100%. Sensitivity is only 10% for ocular myasthenia. Specificity not assessed, though anecdotes put it at 70-80%.

The test is done by repetitively stimulating a nerve and looking at the muscular response; at 2 Hz stimulation, the amplitude of response should decrease over time. At higher frequency stimulation, there is a variable response (i.e. decrease or constant amplitude) because of increased calcium in the synaptic cleft.

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Associated Diagnoses:

Myasthenia Gravis

53% sensitive