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Wilson's Disease: Sensitivity and Specificity

Introduction: aka hepatolenticular degeneration

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Tags: Congenital Hepatic Metabolic Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Asymptomatic individuals 0.03% J Hepatol. 1997 Aug;27(2):358-62. PMID: 9288611
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The sensitivity and specificity of findings for Wilson's Disease are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
FindingResult SensitivitySpecificity
[ + ] Ceruloplasmin, low serum levels + 0 - 88%99%
[ + ] Elevated Urine Copper Sensitivity = 87%
[ + ] Genetic Testing No accuracy specified.
[ + ] Kayser-Fleischer Ring Sensitivity = 66%
[ + ] Liver Copper Content + 0 - 83%99%
[ + ] Liver Copper Content + 0 - 97%95%
[ + ] Serum Copper Sensitivity = 87%
[ + ] Urine Copper after Penicillamine Challenge + 0 - 76%93%