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Good Positive and Negative Likelihood Ratios

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Wilson's Disease: Likelihood Ratios

Introduction: aka hepatolenticular degeneration

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Tags: Congenital Hepatic Metabolic Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Asymptomatic individuals 0.03% J Hepatol. 1997 Aug;27(2):358-62. PMID: 9288611
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The likelihood ratios of findings for Wilson's Disease are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Good Positive and Negative Likelihood Ratios
FindingResult +LR-LR
[ + ] Liver Copper Content + 0 - 19.40
[ + ] Ceruloplasmin, low serum levels + 0 - 880.1
[ + ] Liver Copper Content + 0 - 830.2
[ + ] Urine Copper after Penicillamine Challenge + 0 - 10.90.3
Poorly Diagnostic Findings
FindingResult +LR-LR
[ + ] Elevated Urine Copper Sensitivity = 87%
[ + ] Serum Copper Sensitivity = 87%
[ + ] Kayser-Fleischer Ring Sensitivity = 66%
Findings With Unspecified Accuracy
FindingResult +LR-LR
[ + ] Genetic Testing No accuracy specified.