Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)


Finding	Result	Sensitivity	Specificity
[ + ] ACR Criteria	+ 0 -	88%	92%
2 of the 4 criteria must be met from the 1990 Criteria for the Classification of Wegener's Granulomatosis: 1. Nasal or oral inflammation Development of painful or painless oral ulcers or purulent or bloody nasal discharge 2. Abnormal chest radiograph Chest radiograph showing the presence of nodules, fixed infiltrates, or cavities 3. Urinary sediment Microhematuria (>5 red blood cells per high power field) or red cell casts in urine sediment 4. Granulomatous inflammation on biopsy Histologic changes showing granulomatous inflammation within the wall of an artery or in the perivascular or extravascular area (artery or arteriole) Study: PMID 2202308 Leavitt RY, Fauci AS, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum. Aug 1990;33(8):1101-1107.
[ + ] anti-MPO	+ 0 -	24%	91%
specificity vs healthy people Study: Kidney Int. 1998 Mar;53(3):743-53. PMID: 9507222
[ + ] anti-PR3	+ 0 -	66%	87%
specificity vs healthy people Study: Kidney Int. 1998 Mar;53(3):743-53. PMID: 9507222
[ + ] c-ANCA	+ 0 -	91%	99%
for active disease Study: Ann Intern Med. 1995 Dec 15;123(12):925-32. PMID: 7486487
[ + ] c-ANCA	+ 0 -	63%	100%
for inactive disease Study: Ann Intern Med. 1995 Dec 15;123(12):925-32. PMID: 7486487
[ + ] c-ANCA	+ 0 -	64%	95%
specificity vs healthy people Study: Kidney Int. 1998 Mar;53(3):743-53. PMID: 9507222
[ + ] c-ANCA and anti-PR3	+ 0 -	73%	99%
specificity vs healthy people Study: Kidney Int. 1998 Mar;53(3):743-53. PMID: 9507222
[ + ] Erythematous painful pinna		No accuracy specified.
Study: no study specified.
[ + ] Leukopenia		No accuracy specified.
Leukopenia is NOT a feature of WG. A Leukocyte count < 4000/mm3 can be seen in patients with lymphomatoid granulomatosis which evolves into lymphoma. It is often confused with WG. Study: PMID 6336643 See pages 79-80: Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983 Jan;98(1):76-85. Review. PubMed PMID: 6336643.
[ + ] p-ANCA	+ 0 -	21%	81%
specificity vs healthy people Study: Kidney Int. 1998 Mar;53(3):743-53. PMID: 9507222
[ + ] Sensorineural hearing loss (SNHL)		No accuracy specified.
2.8 to 13% incidence of SNHL in WG patients. Study: Hearing loss in Wegener's granulomatosis. Bakthavachalam S, Driver MS, Cox C, Spiegel JH, Grundfast KM, Merkel PA. Otol Neurotol. 2004 Sep;25(5):833-7. PMID 15354019