Typhoid Fever: Likelihood Ratios

Introduction: None written.

The likelihood ratios of findings for Typhoid Fever are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Poorly Diagnostic Findings
Finding	Result	+LR	-LR
[ + ] hearing loss		Sensitivity = 90%
>38C 53% of patients had fever >40C Study: Microbiol Immunol. 2000;44(7):577-83. PMID 10981830
[ + ] Bone Marrow Aspirate Culture		Sensitivity = 85.6%
Study: J Infect Dis 1984 Feb;149(2):157-61 PMID 6421940
[ + ] Blood Cultures		Sensitivity = 81%
Study: Microbiol Immunol. 2000;44(7):577-83. PMID 10981830
[ + ] Duodenal string-capsule culture		Sensitivity = 57.6%
Study: J Infect Dis 1984 Feb;149(2):157-61 PMID 6421940
[ + ] Diarrhea		Sensitivity = 56%
Study: Microbiol Immunol. 2000;44(7):577-83. PMID 10981830
[ + ] Blood Cultures		Sensitivity = 54.2%
Study: J Infect Dis 1984 Feb;149(2):157-61 PMID 6421940
[ + ] Stool Culture		Sensitivity = 50%
Study: Microbiol Immunol. 2000;44(7):577-83. PMID 10981830
[ + ] Rectal Swab Culture		Sensitivity = 35.6%
Study: J Infect Dis 1984 Feb;149(2):157-61 PMID 6421940
[ + ] Rose Spots		Sensitivity = 26%
salmon colored spots usually found on the abdomen Study: Microbiol Immunol. 2000;44(7):577-83. PMID 10981830
[ + ] Hepatomegaly		Sensitivity = 25%
Study: Microbiol Immunol. 2000;44(7):577-83. PMID 10981830
[ + ] Leukocytosis		Sensitivity = 17%
>8k/ul Study: Microbiol Immunol. 2000;44(7):577-83. PMID 10981830