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Tuberculous Pleural Effusion: Sensitivity and Specificity

Introduction: Tuberculosis can cause exudative pleural effusions and is notoriously difficult to diagnose. The effusion is reactive and often does not contain mycobacteria. See also Exudative Pleural Effusion and Tuberculosis.

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The sensitivity and specificity of findings for Tuberculous Pleural Effusion are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Elevated total protein Sensitivity = 98.8%
[ + ] Adenosine Deaminase + 0 - 93.8%82.5%
[ + ] Lymphocytic Predominance Sensitivity = 93.3%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Pleural Biopsy Sensitivity = 79.8%
[ + ] Purified Protein Derivative (PPD) Sensitivity = 66.5%