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Good Positive and Negative Likelihood Ratios

Good Negative Likelihood Ratio

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Tricyclic Antidepressant Toxicity: Likelihood Ratios

Introduction: Overdose of tricyclic antidepressants can lead to a number of serious side effects, including cardiac arrhythmias (ventricular and blocks), seizures, and anticholinergic delirium.

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Tags: Toxic Tag this Diagnosis.

The likelihood ratios of findings for Tricyclic Antidepressant Toxicity are listed below. See the left navigation bar to change the display.

Good Positive and Negative Likelihood Ratios

Finding +LR-LR Comments, Study
ECG R/S Ratio Edit 15.70.5

R/S ratio > 0.7 for ventricular arrhythmias

Study: J Toxicol Clin Toxicol. 2004;42(6):877-88. PMID: 15533027

Good Negative Likelihood Ratio

Finding +LR-LR Comments, Study
TCA Level Edit 1.80.4

for ventricular arrhythmia. For seizures, Sens 75% Spec 72%

Study: J Toxicol Clin Toxicol. 2004;42(6):877-88. PMID: 15533027

Prolonged QTc Edit 1.80.4

QTc > 430ms. for ventricular arrhythmias

Study: J Toxicol Clin Toxicol. 2004;42(6):877-88. PMID: 15533027

Wide QRS Edit 1.50.5

QRS > 0.1 s

for ventricular arrhythmias. For seizures, Sens 69% and Spec 69%.

Study: J Toxicol Clin Toxicol. 2004;42(6):877-88. PMID: 15533027

Poorly Diagnostic Findings

Finding +LR-LR Comments, Study
Terminal QRS Axis Edit 1.10.9

Right axis deviation of 120-270 degrees in the terminal 40ms frontal plane QRS vector

for ventricular arrhythmias

Study: J Toxicol Clin Toxicol. 2004;42(6):877-88. PMID: 15533027