Thalassemia: Sensitivity and Specificity
Introduction: Thalassemia is in the differential diagnosis of a microcytic anemia. The two other categories of microcytic anemia are Iron Deficiency Anemia and Anemia of Chronic Disease. There are a number of different 'indices' that one can use to distinguish IDA from thalassemia (see below), but iron studies / ferritin are probably more accurate.
I have chosen to simply paste in references here because the numbers are rather discordant among the studies.
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J Int Med Res. 2009 Jan-Feb;37(1):25-30. PMID: 19215670
Pediatr Int. 2002 Dec;44(6):612-6. PMID: 12421257
Ann Hematol. 2007 Jul;86(7):487-91. PMID: 17476506
Differential Diagnoses include: Iron Deficiency Anemia