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Temporal Arteritis: Sensitivity and Specificity

Introduction: also known as Giant Cell Arteritis.

The estimated 5-year probability of developing visual loss after initiating corticosteroid therapy was 1%; that of additional visual loss in patients who already had visual loss was 13%.

Symptoms not specific to TA: anorexia, arthralgia, fatigue, fever, temporal headache, myalgia or polymyalgia rheumatica, unilateral vision loss or any visual sx, vertigo

Signs not specific to TA: optic atrophy/neuropathy, fundoscopic abnormality, absent temporal artery pulse, anemia.

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Tags: Autoimmune Vasculitis Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Age < 50 0% only 2/1435 patients with temporal arteritis were <50.

JAMA 2002 Jan 2;287(1):92-101. PMID 11754714

Women 0% more common than in men
Patients referred for TA biopsy 39% JAMA. 2002;287:92-101. http://jama.ama-assn.org/cgi/content/full/287/1/92
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The sensitivity and specificity of findings for Temporal Arteritis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Temporal Artery Biopsy + 0 - 87.1%100%
[ + ] ACR Criteria + 0 - 94%91%
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Beaded temporal artery + 0 - 9%98%
[ + ] Diplopia + 0 - 7%98%
[ + ] Jaw claudication + 0 - 34%92%
[ + ] Tender temporal artery + 0 - 26%90%
[ + ] Scalp tenderness + 0 - 17%90%
[ + ] Synovitis + 0 - 6%86%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Elevated ESR + 0 - 98%11%
[ + ] Elevated ESR + 0 - 92%24%
Negative Findings
FindingResult SensitivitySpecificity
[ + ] Synovitis + 0 - 6%86%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Elevated ESR + 0 - 35%82%
[ + ] Temporal Headache + 0 - 40%74%
[ + ] Weight loss + 0 - 35%73%
[ + ] Headache + 0 - 72%40%