Takayasu's Arteritis: Sensitivity and Specificity

Introduction: also known as Pulseless Disease.

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Tags: Inflammatory Vascular Vasculitis Tag this Diagnosis.

The sensitivity and specificity of findings for Takayasu's Arteritis are listed below. See the left navigation bar to change the display.

Combination of Tests

ACR Criteria

90.5%

97.8%

>=3/6 criteria:

Age at disease onset ≤40 years

Claudication of the extremities

Decreased pulsation of one or both brachial arteries

Difference of at least 10 mmHg in systolic blood pressure between the arms

Bruit over one or both subclavian arteries or the abdominal aorta

Arteriographic narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities, not due to arteriosclerosis, fibromuscular dysplasia, or other causes

Study: Arthritis Rheum 1990 Aug;33(8):1129-34. PMID 1975175

Imaging

CT angiography

95%

100%

in patients suspected of having Takayasu's

Study: Radiology. 1998 Oct;209(1):103-9. PMID 9769819

Ultrasound

55%

94%

halo sign on Ultrasound. Gold standard was ACR criteria (for gold standard of biopsy, sens=69%/spec=82%). Stenosis or occlusion had similar sensitivities to halo sign.

Study: Ann Intern Med. 2005 Mar 1;142(5):359-69 PMID 15738455

Untagged

Gender

Sensitivity = 85%

85% of those affected are women. Onset is usually <20, or more broadly 10-40 years of age. Prevalence is far greater in Asians.

Study: Am Heart J 1977 Jan;93(1):94-103. PMID 12655