Takayasu's Arteritis: Likelihood Ratios

Introduction: also known as Pulseless Disease.

The likelihood ratios of findings for Takayasu's Arteritis are listed below. See the left navigation bar to change the display.

Good Positive and Negative Likelihood Ratios

Finding	+LR	-LR	Comments, Study
CT angiography	inf	0.1	in patients suspected of having Takayasu's Study: Radiology. 1998 Oct;209(1):103-9. PMID 9769819
ACR Criteria	41.1	0.1	>=3/6 criteria: Age at disease onset ≤40 years Claudication of the extremities Decreased pulsation of one or both brachial arteries Difference of at least 10 mmHg in systolic blood pressure between the arms Bruit over one or both subclavian arteries or the abdominal aorta Arteriographic narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities, not due to arteriosclerosis, fibromuscular dysplasia, or other causes Study: Arthritis Rheum 1990 Aug;33(8):1129-34. PMID 1975175
Ultrasound	9.2	0.5	halo sign on Ultrasound. Gold standard was ACR criteria (for gold standard of biopsy, sens=69%/spec=82%). Stenosis or occlusion had similar sensitivities to halo sign. Study: Ann Intern Med. 2005 Mar 1;142(5):359-69 PMID 15738455

Poorly Diagnostic Findings

Sensitivity = 85%

85% of those affected are women. Onset is usually <20, or more broadly 10-40 years of age. Prevalence is far greater in Asians.

Study: Am Heart J 1977 Jan;93(1):94-103. PMID 12655