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Sensitive and Specific Findings

Specific Findings

Sensitive Findings

Takayasu's Arteritis: Sensitivity and Specificity

Introduction: also known as Pulseless Disease.

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Tags: Inflammatory Vascular Vasculitis Tag this Diagnosis.

The sensitivity and specificity of findings for Takayasu's Arteritis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Sensitive and Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] CT angiography	+ 0 -	95%	100%
in patients suspected of having Takayasu's Study: Radiology. 1998 Oct;209(1):103-9. PMID 9769819
[ + ] ACR Criteria	+ 0 -	90.5%	97.8%
>=3/6 criteria: Age at disease onset ≤40 years Claudication of the extremities Decreased pulsation of one or both brachial arteries Difference of at least 10 mmHg in systolic blood pressure between the arms Bruit over one or both subclavian arteries or the abdominal aorta Arteriographic narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities, not due to arteriosclerosis, fibromuscular dysplasia, or other causes Study: Arthritis Rheum 1990 Aug;33(8):1129-34. PMID 1975175

Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Ultrasound	+ 0 -	55%	94%
halo sign on Ultrasound. Gold standard was ACR criteria (for gold standard of biopsy, sens=69%/spec=82%). Stenosis or occlusion had similar sensitivities to halo sign. Study: Ann Intern Med. 2005 Mar 1;142(5):359-69 PMID 15738455

Sensitive Findings
Finding	Result	Sensitivity	Specificity
[ + ] Gender		Sensitivity = 85%
85% of those affected are women. Onset is usually <20, or more broadly 10-40 years of age. Prevalence is far greater in Asians. Study: Am Heart J 1977 Jan;93(1):94-103. PMID 12655