Syndrome of Inappropriate ADH Secretion: Sensitivity and Specificity
Introduction: SIADH a major cause of hyponatremia and represents the condition when a euvolemic patient has increased ADH causing inappropriate retention of free water. The diagnosis is important as the treatment is fluid restriction rather than normal saline infusion.
For a review of the diagnosis, see http://cjasn.asnjournals.org/cgi/content/full/3/4/1175 (PMID 18434618)
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Differential Diagnoses include: Hypovolemia
Prevalence
| Population / Calculator | Prevalence | Comments / Study / Link |
| Elderly patients with hyponatremia | 31% | 110 consecutive cases: 31% SIADH patients, 23% patients with hyponatremia due to diuretics, 18% potomania patients, 15% salt depleted patients, 5% salt depleted SIADH patients, 5% patients with a salt loosing syndrome and 3% patients with hyponatremia of unknown origin
Int Urol Nephrol. 2001;32(3):475-93. PMID: 11583374 |
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The sensitivity and specificity of findings for Syndrome of Inappropriate ADH Secretion are listed below. See the left navigation bar to change the display.