Syndrome of Inappropriate ADH Secretion: Sensitivity and Specificity
Introduction: SIADH a major cause of hyponatremia and represents the condition when a euvolemic patient has increased ADH causing inappropriate retention of free water. The diagnosis is important as the treatment is fluid restriction rather than normal saline infusion.
For a review of the diagnosis, see http://cjasn.asnjournals.org/cgi/content/full/3/4/1175 (PMID 18434618)
Differential Diagnoses include: Hypovolemia
|Population / Calculator||Prevalence||Comments / Study / Link|
|Elderly patients with hyponatremia||31%||110 consecutive cases: 31% SIADH patients, 23% patients with hyponatremia due to diuretics, 18% potomania patients, 15% salt depleted patients, 5% salt depleted SIADH patients, 5% patients with a salt loosing syndrome and 3% patients with hyponatremia of unknown origin
Int Urol Nephrol. 2001;32(3):475-93. PMID: 11583374