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Spontaneous Bacterial Peritonitis: Sensitivity and Specificity

Introduction: This diagnosis carries a high mortality rate, around 30%. Diagnostic paracentesis is critical in the diagnosis (and may be therapeutic in non-infective ascites).

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Tags: Hepatic Infection Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Cirrhosis patients admitted to the hospital 27% JAMA. 2008;299(10):1166-1178. http://jama.ama-assn.org/cgi/content/full/299/10/1166
Cirrhosis patients with prior SBP 0% Much higher prevalence - these patients are placed on prophylactic antibiotics.
Cirrhosis patients with low ascitic protein 0% Much higher. These patients get prophylactic antibiotics.
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The sensitivity and specificity of findings for Spontaneous Bacterial Peritonitis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Ascitic Fluid PMN + 0 - 85%92%
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Ascitic Fluid WBC + 0 - 77%92%
[ + ] Ascitic Fluid pH + 0 - 71%92%
[ + ] Blood-Ascites pH Gradient + 0 - 73%90%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Serum-Ascites Albumin Gradient + 0 - 95%79%

 

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