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Poorly Diagnostic Findings

Splenomegaly: Sensitivity and Specificity

Introduction: Splenomegaly, an enlarged spleen, may be found in many diagnoses, including infectious mononucleosis, lymphoma, and cirrhosis. Generally accepted cutoffs for an enlarged spleen are >250g, 12-13cm in length, 7cm in width, or 250cc in volume (PMID 8411607).

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The sensitivity and specificity of findings for Splenomegaly are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Physical Exam + 0 - 20%100%
[ + ] Percussion + 0 - 59%94%
[ + ] Middleton's Maneuver + 0 - 56%93%
[ + ] Palpation + 0 - 58%92%
[ + ] Palpation + 0 - 71%90%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Percussion + 0 - 82%83%
[ + ] Percussion + 0 - 62%72%
[ + ] Palpation + 0 - 56%69%