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Serious Bacterial Infection: Sensitivity and Specificity

Introduction: None written.

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Tags: Infection Tag this Diagnosis.

Prevalence

Population / Calculator	Prevalence	Comments / Study / Link
Children presenting with fever	20%	J Pediatr. 2008 Oct;153(4):570-4 PMID: 18534215
Children < 5 yr with fever	7.2%	defined as UTI/PNA/bacteremia BMJ. 2010 Apr 20;340:c1594. doi: 10.1136/bmj.c1594 PMID: 20406860
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The sensitivity and specificity of findings for Serious Bacterial Infection are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Clinical diagnosis	+ 0 -	50%	90%
numbers are general estimates... see the figures for actual ROC curve Study: BMJ. 2010 Apr 20;340:c1594. doi: 10.1136/bmj.c1594 PMID: 20406860

Poorly Diagnostic Findings
Finding	Result	Sensitivity	Specificity
[ + ] Elevated CRP	+ 0 -	77%	79%
In children presenting with fever, serious bacterial vs benign or nonbacterial infection. Study: J Pediatr. 2008 Oct;153(4):570-4 PMID: 18534215