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Pernicious Anemia: Sensitivity and Specificity

Introduction: Autoimmune attack of the parietal cells in the stomach that are responsible for producing intrinsic factor. Intrinsic factor is necessary for the absorption of vitamin B12 (cobalamin), thus its loss causes Megaloblastic Anemia.

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Tags: Autoimmune Hematologic Tag this Diagnosis.

The sensitivity and specificity of findings for Pernicious Anemia are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Anti-parietal Cell Antibody + 0 - 85%90%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Elevated Fasting Serum Gastrin Sensitivity = 90%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Anti-Intrinsic Factor Antibodies Sensitivity = 50%