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Parkinson's Disease: Likelihood Ratios

Introduction: Specifically, idiopathic Parkinson's. The differential diagnosis would include Essential Tremor, Parkinson's-Plus syndromes (Multi-System Atrophy, Progressive Supranuclear Palsy, Dementia with Lewy Bodies), and secondary Parkinson's (toxic such as MPTP, traumatic such as dementia pugilistica).

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Tags: Neurologic Tag this Diagnosis.

The likelihood ratios of findings for Parkinson's Disease are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Good Positive and Negative Likelihood Ratios
FindingResult +LR-LR
[ + ] Can Ride a Bicycle + 0 - 20.1
[ + ] Levodopa Challenge + 0 - 3.70.4
[ + ] Cardinal Features + 0 - 2.80.4
[ + ] Resting Tremor + 0 - 20.5
Good Negative Likelihood Ratio
FindingResult +LR-LR
[ + ] Levodopa Responsiveness + 0 - 1.30.2
[ + ] Asymmetric Onset + 0 - 1.70.5
Poorly Diagnostic Findings
FindingResult +LR-LR
[ + ] Rigidity Sensitivity = 89%
[ + ] Bradykinesia Sensitivity = 77%
[ + ] Postural Instability Sensitivity = 37%