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Good Positive and Negative Likelihood Ratios

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Neuroblastoma: Likelihood Ratios

Introduction: None written.

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Tags: Neoplasm Pediatrics Tag this Diagnosis.

The likelihood ratios of findings for Neuroblastoma are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Good Positive and Negative Likelihood Ratios
Finding	Result	+LR	-LR
[ + ] VMA / Cr Ratio	+ 0 -	6.7	0.1
from urine. Ratio was compared to a floating median. Study: Ann Clin Biochem. 2006 Jul;43(Pt 4):300-5. PMID: 16824281
[ + ] Dopamine / Cr Ratio	+ 0 -	3.6	0.4
from urine Study: Ann Clin Biochem. 2006 Jul;43(Pt 4):300-5. PMID: 16824281

Poorly Diagnostic Findings
Finding	Result	+LR	-LR
[ + ] Urine Elevated VMA, HA, or DA		Sensitivity = 91.2%
specificity not assessed Study: Ann Clin Biochem. 2006 Jul;43(Pt 4):300-5. PMID: 16824281
[ + ] Urine Vanillylmandelic Acid		Sensitivity = 80.7%
specificity not assessed Study: Ann Clin Biochem. 2006 Jul;43(Pt 4):300-5. PMID: 16824281
[ + ] Urine Homovanillic Acid		Sensitivity = 71.9%
specificity not assessed Study: Ann Clin Biochem. 2006 Jul;43(Pt 4):300-5. PMID: 16824281
[ + ] Urine Dopamine		Sensitivity = 61.3%
specificity not assessed Study: Ann Clin Biochem. 2006 Jul;43(Pt 4):300-5. PMID: 16824281