Neonatal Hyperbilirubinemia: Sensitivity and Specificity

Introduction: aka neonatal jaundice. Use the Bhutani nomogram ( http://www.bilitool.org ) to evaluate the risk of progression to kernicterus and requirement for phototherapy.

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Prevalence

The sensitivity and specificity of findings for Neonatal Hyperbilirubinemia are listed below. See the left navigation bar to change the display.

Sensitive Findings

Finding	Sensitivity	Specificity	Comments, Study
Jaundice at the Abdomen	97%	19%	between the nipple line and the umbilicus, for TBili >=12.0mg/dl. Mean age = 2 days. Study: Arch Pediatr Adolesc Med. 2000 Apr;154(4):391-4. PMID: 10768679

Poorly Diagnostic Findings

Finding	Sensitivity	Specificity	Comments, Study
Jaundice	81%	71%	"clinical jaundice" by neonatologists, at ~70 hours of life. For TBili > 12mg/dl Study: Clin Pediatr (Phila). 2003 Mar;42(2):153-8. PMID: 12659389