Multiple Myeloma: Sensitivity and Specificity

Introduction: Multiple myeloma is a plasma cell neoplasm producing a large amount of an immunoglobulin (IgG) causing end-organ damage. In particular, the patient must meet the following 3 criteria:

Presence of a monoclonal protein in the serum and/or urine

Presence of monoclonal plasma cells in the bone marrow >10%

Presence of end-organ damage: hypercalcemia, renal insufficiency, anemia, or lytic bone lesions

Diagnosis of a monoclonal proteinopathy proceeds with SPEP, UPEP, free light chains (FLC).

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Tags: Hematologic Neoplasm Tag this Diagnosis.

The sensitivity and specificity of findings for Multiple Myeloma are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Blood Test
Finding	Result	Sensitivity	Specificity
[ + ] Hypercalcemia		Sensitivity = 30%
specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582
[ + ] Hypogammaglobulinemia		Sensitivity = 9%
specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582
[ + ] Renal Insufficiency		Sensitivity = 55%
specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582
[ + ] Serum Free Light Chains	+ 0 -	88%	98%
Patients with k/l ratios >1.65 or <0.26 are identified as producing clonal {kappa} or {lambda} FLCs, respectively. Study: Ann Clin Lab Sci. 2006 Spring;36(2):157-62. PMID: 16682511
[ + ] Serum Immunofixation Electrophoresis		Sensitivity = 93%
specificity not assessed. For patients defined by abnormal urine immunofixation electrophoresis. Study: Mayo Clin Proc. 2006 Dec;81(12):1575-8. PMID: 17165636
[ + ] SPEP	+ 0 -	64%	81%
aka Serum Protein Electrophoresis The presence of one or more distinct peaks not corresponding to the usual protein bands in the gamma or beta globulin regions indicated the possible presence of a monoclonal or polyclonal gammopathy. Study: Ann Clin Lab Sci. 2006 Spring;36(2):157-62. PMID: 16682511
[ + ] SPEP and FLC	+ 0 -	100%	99%
Study: Ann Clin Lab Sci. 2006 Spring;36(2):157-62. PMID: 16682511

Combination of Tests
Finding	Result	Sensitivity	Specificity
[ + ] SPEP and FLC	+ 0 -	100%	99%
Study: Ann Clin Lab Sci. 2006 Spring;36(2):157-62. PMID: 16682511

Imaging
Finding	Result	Sensitivity	Specificity
[ + ] X-Ray		Sensitivity = 79%
specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582

Physical Exam
Finding	Result	Sensitivity	Specificity
[ + ] Palpable Liver		Sensitivity = 21%
specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582
[ + ] Palpable Spleen		Sensitivity = 5%
specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582

Urine Test
Finding	Result	Sensitivity	Specificity
[ + ] Bence-Jones Proteinuria		Sensitivity = 49%
monoclonal light chains in urine specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582
[ + ] Proteinuria		Sensitivity = 88%
specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582
[ + ] UPEP		Sensitivity = 75%
globulin spike specificity not assessed Study: Mayo Clin Proc. 1975 Jan;50(1):29-40. PMID: 1110582