Multiple Myeloma: Sensitivity and Specificity
Introduction: Multiple myeloma is a plasma cell neoplasm producing a large amount of an immunoglobulin (IgG) causing end-organ damage. In particular, the patient must meet the following 3 criteria:
Presence of a monoclonal protein in the serum and/or urine
Presence of monoclonal plasma cells in the bone marrow >10%
Presence of end-organ damage: hypercalcemia, renal insufficiency, anemia, or lytic bone lesions
Diagnosis of a monoclonal proteinopathy proceeds with SPEP, UPEP, free light chains (FLC).
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The sensitivity and specificity
of findings for Multiple Myeloma are listed below.
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