Menopause: Sensitivity and Specificity

Introduction: Two good articles:

and J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

The sensitivity and specificity of findings for Menopause are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)


Finding	Result	Sensitivity	Specificity
[ + ] Age	+ 0 -	35%	98%
>= 50 years Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Amenorrhea	+ 0 -	20%	99%
3-12 month duration Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Change in Menstrual Flow	+ 0 -	81%	30%
Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Elevated FSH	+ 0 -	69%	86%
>20 or >24 IU/l, depending on study Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Hot Flashes	+ 0 -	40%	87%
Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Inhibin	+ 0 -	7%	96%
inhibin immunoreactivity Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Inhibin	+ 0 -	61%	54%
inhibin A Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Inhibin	+ 0 -	46%	78%
inhibin B Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Menstrual Irregularity	+ 0 -	66%	81%
within last 12 months Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Night Sweats	+ 0 -	35%	80%
Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Patient Thinks She is Perimenopausal	+ 0 -	85%	51%
Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610
[ + ] Vaginal Dryness	+ 0 -	20%	88%
Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610