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Menopause: Sensitivity and Specificity

Introduction: Two good articles:

Bastian, et al. JAMA 2003 http://jama.ama-assn.org/cgi/content/full/289/7/895

and J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

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Tags: Endocrine Gynecologic Tag this Diagnosis.

The sensitivity and specificity of findings for Menopause are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Amenorrhea + 0 - 20%99%
[ + ] Age + 0 - 35%98%
[ + ] Inhibin + 0 - 7%96%
[ + ] Vaginal Dryness + 0 - 20%88%
[ + ] Hot Flashes + 0 - 40%87%
[ + ] Elevated FSH + 0 - 69%86%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Patient Thinks She is Perimenopausal + 0 - 85%51%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Menstrual Irregularity + 0 - 66%81%
[ + ] Night Sweats + 0 - 35%80%
[ + ] Inhibin + 0 - 46%78%
[ + ] Inhibin + 0 - 61%54%
[ + ] Change in Menstrual Flow + 0 - 81%30%