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Menopause: Sensitivity and Specificity

Introduction: Two good articles:

Bastian, et al. JAMA 2003 http://jama.ama-assn.org/cgi/content/full/289/7/895

and J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

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Tags: Endocrine Gynecologic Tag this Diagnosis.

The sensitivity and specificity of findings for Menopause are listed below. See the left navigation bar to change the display.

Specific Findings

Finding SensitivitySpecificity Comments, Study
Amenorrhea Edit 20%99%

3-12 month duration

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Age Edit 35%98%

>= 50 years

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Inhibin
Duplicate Edit
7%96%

inhibin immunoreactivity

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Vaginal Dryness Edit 20%88%

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Hot Flashes Edit 40%87%

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Elevated FSH Edit 69%86%

>20 or >24 IU/l, depending on study

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Sensitive Findings

Finding SensitivitySpecificity Comments, Study
Patient Thinks She is Perimenopausal Edit 85%51%

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Poorly Diagnostic Findings

Finding SensitivitySpecificity Comments, Study
Menstrual Irregularity Edit 66%81%

within last 12 months

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Night Sweats Edit 35%80%

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Inhibin
Duplicate Edit
46%78%

inhibin B

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Inhibin
Duplicate Edit
61%54%

inhibin A

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610

Change in Menstrual Flow Edit 81%30%

Study: J Fam Pract. 2005 Nov;54(11):1000-2. PMID: 16266610