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Poorly Diagnostic Findings

Liver Disease: Sensitivity and Specificity

Introduction: Liver disease can have many etiologies, including acute and chronic viral hepatitides (Hepatitis B and Hepatitis C), Alcoholism, obesity, and autoimmune disorders. "Liver function tests" or LFTs reflect hepatitis, and there are two major categories of LFTs: synthetic outputs of the liver (albumin, coagulation factors, etc.) and hepatocyte enzymes (aminotransferases).

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Tags: Hepatic Infection Inflammatory Tag this Diagnosis.

The sensitivity and specificity of findings for Liver Disease are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Serum Bile Acids + 0 - 78%93%
[ + ] Elevated AST + 0 - 74%92%
[ + ] Elevated Total Bilirubin + 0 - 56%91%
[ + ] Elevated ALT + 0 - 56%90%
[ + ] Prealbumin (Transthyretin) + 0 - 84%89.2%
[ + ] Prothrombin Activity + 0 - 63%89.2%
[ + ] Apolipoprotein A + 0 - 53.4%86.1%
[ + ] Albumin + 0 - 41.6%85.9%
[ + ] Elevated GGT + 0 - 75%85%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Elevated Alkaline Phosphatase + 0 - 65%83%
[ + ] Pseudocholinesterase + 0 - 69.8%69.8%