GetTheDiagnosis.org

Welcome, guest.
Login or Sign up to edit.

Add an entry

Search:
 

Tools

Add a finding for this diagnosis

Add prevalence for this diagnosis

Switch to display mode

Switch to likelihood ratios

Sort findings by Tag

Sort findings by Differential Diagnosis

Jump To

Specific Findings

Sensitive Findings

Poorly Diagnostic Findings

Kawasaki Disease: Sensitivity and Specificity

Introduction: Kawasaki disease is a difficult disease to diagnose. The diagnosis relies on a constellation of symptoms.

[The following is taken from review article by Burns and Glode cited below]

The diagnosis is confirmed by the presence of fever for at least 5 days and of four of the five criteria below, and by the lack of another known disease process to explain the illness.

  • Bilateral conjunctival injection
  • Changes of the mucous membranes of the upper respiratory tract: injected pharynx; injected, fissured lips; strawberry tongue
  • Polymorphous rash
  • Changes of the extremities: peripheral oedema, peripheral erythema, periungual desquamation
  • Cervical adenopathy
  • The following is a review article on Kawasaki disease that includes an extensive differential diagnosis for each of the important symptoms in the constellation of findings that define Kawasaki disease: Burns JC, Glodé MP. "Kawasaki syndrome." 1: Lancet. 2004 Aug 7-13;364(9433):533-44. PMID: 18387169

    [Edit Diagnosis] [Merge dx] [Add prevalence]

    Tags: Autoimmune Pediatrics Vasculitis Tag this Diagnosis.

    Differential Diagnoses include: Acute Streptococcal Pharyngitis

    The sensitivity and specificity of findings for Kawasaki Disease are listed below. See the left navigation bar to change the display.

    Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
    **Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
    Specific Findings
    FindingResult SensitivitySpecificity
    [ + ] Elevated ALT + 0 - 18.1%100%
    [ + ] Anemia and Elevated ESR + 0 - 54.4%92.3%
    [ + ] Residence near Water + 0 - 41.1%85.7%
    Sensitive Findings
    FindingResult SensitivitySpecificity
    [ + ] Clinical Criteria + 0 - 90%54%
    Poorly Diagnostic Findings
    FindingResult SensitivitySpecificity
    [ + ] Elevated ESR + 0 - 59.8%82.8%