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Hypothyroidism: Sensitivity and Specificity

Introduction: None written.

[Edit Diagnosis] [Merge dx] [Add prevalence]

Tags: Endocrine Tag this Diagnosis.

The sensitivity and specificity of findings for Hypothyroidism are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
TSH
Duplicate Edit		 92%93%

exact sens / spec depends on the particular TSH assay used

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228
Free T3 Edit 86%88%

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228

Specific Findings

Finding SensitivitySpecificity Comments, Study
Slow Movements Edit 36%99%

Note that another study [PMID: 15047991] gave sens = 87%, spec = 13%.

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Hearing Loss Edit 22%98%

progressive

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Periorbital Puffiness Edit 60%96%

obscuring the curve of the malar bone.

Note that another study [PMID: 15047991] gave sens = 92% / spec = 21%.

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Free T4
Duplicate Edit		 82%94%

estimated

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228
Achilles Reflex Edit 77%94%

delayed relaxation time

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Free T4
Duplicate Edit		 78%93%

calculated

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228
Hoarseness Edit 34%88%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Decreased Sweating Edit 54%86%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Constipation Edit 48%85%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Poorly Diagnostic Findings

Finding SensitivitySpecificity Comments, Study
Paresthesias Edit 52%83%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Coarse Skin Edit 60%81%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Cold Skin Edit 50%80%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Weight Gain Edit 54%77%

or tightness of clothes

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Cold Intolerance Edit 64%65%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Dry Skin Edit 76%64%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Bradycardia Edit 58%42%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480
Peripheral Edema Edit 78%30%

specifically pre-tibial

Study: J Postgrad Med. 2004 Jan-Mar;50(1):7-11. PMID: 15047991

Findings With Unspecified Accuracy

Finding SensitivitySpecificity Comments, Study
TSH
Duplicate Edit		 No accuracy specified.

Study: no study specified.

 

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