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Sensitive and Specific Findings

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Hypothyroidism: Sensitivity and Specificity

Introduction: None written.

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Tags: Endocrine Tag this Diagnosis.

The sensitivity and specificity of findings for Hypothyroidism are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
TSH Edit 92%93%

exact sens / spec depends on the particular TSH assay used

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228

Free T3 Edit 86%88%

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228

Specific Findings

Finding SensitivitySpecificity Comments, Study
Slow Movements Edit 36%99%

Note that another study [PMID: 15047991] gave sens = 87%, spec = 13%.

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Hearing Loss Edit 22%98%

progressive

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Periorbital Puffiness Edit 60%96%

obscuring the curve of the malar bone.

Note that another study [PMID: 15047991] gave sens = 92% / spec = 21%.

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Free T4
Duplicate Edit
82%94%

estimated

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228

Achilles Reflex Edit 77%94%

delayed relaxation time

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Free T4
Duplicate Edit
78%93%

calculated

Study: Arch Intern Med 1989 Mar;149(3):526-32. PMID 2493228

Hoarseness Edit 34%88%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Decreased Sweating Edit 54%86%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Constipation Edit 48%85%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Poorly Diagnostic Findings

Finding SensitivitySpecificity Comments, Study
Paresthesias Edit 52%83%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Coarse Skin Edit 60%81%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Cold Skin Edit 50%80%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Weight Gain Edit 54%77%

or tightness of clothes

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Cold Intolerance Edit 64%65%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Dry Skin Edit 76%64%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Bradycardia Edit 58%42%

Study: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6. PMID: 9062480

Peripheral Edema Edit 78%30%

specifically pre-tibial

Study: J Postgrad Med. 2004 Jan-Mar;50(1):7-11. PMID: 15047991